Cole, whose hits include "This Will Be" and "Unforgettable" which she performed as a virtual duet with dad Nat King Cole -- died from congestive heart failure, although we're told the underlying medical issues were complications from a kidney transplant and Hepatitis C.
Natalie had been very sick recently, cancelling several tour dates in late December including a New Year's Eve concert at Disney Hall in L.A. She also cancelled an upcoming February concert due to illness.
Natalie struggled with substance abuse and was plagued with health problems, suffering from liver disease in 2008. She also underwent chemo for Hepatitis C.
Natalie, who was married 3 times and has a son, was 65.
She died in a Los Angeles hospital.
Natalie Cole was inspired by her dad at an early age and auditioned to sing with him when she was just 11 years old. She was 15 when he died of lung cancer, in 1965.
She began as an R&B singer but later gravitated toward the smooth pop and jazz standards that her father loved.
Cole’s greatest success came with her 1991 album, Unforgettable ... With Love, which paid tribute to her father with reworked versions of some of his best-known songs, including That Sunday That Summer, Too Young and Mona Lisa.
Her voice was spliced with her dad’s in the title cut, offering a delicate duet a quarter-century after his death.
While making the album, Cole told The Associated Press in 1991, she had to “throw out every R&B lick that I had ever learned and every pop trick I had ever learned. With him, the music was in the background and the voice was in the front.”
“I didn’t shed really any real tears until the album was over,” Cole said. “Then I cried a whole lot. When we started the project it was a way of reconnecting with my dad. Then when we did the last song, I had to say goodbye again.”
She was also nominated for an Emmy award in 1992 for a televised performance of her father’s songs.
“That was really my thank you,” she told People magazine in 2006. “I owed that to him.”
Another father-daughter duet, When I Fall in Love, won a 1996 Grammy for best pop collaboration with vocals, and a follow-up album, Still Unforgettable, won for best traditional pop vocal album of 2008.